Protein Name:
AN1-type zinc finger protein 1
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UniprotKB/SwissProt ID: Q8TCF1 (Q8TCF1)
Gene Name:
ZFAND1
Organism: Homo sapiens (Human)
Function: Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress (PubMed:29804830). Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome (PubMed:29804830). This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during recovery from arsenite stress, and hence avoiding aberrant cytoplasmic SGs degradation via autophagy (PubMed:29804830)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, Stress granule
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8TCF1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
260 |
LEYLNDEEQF C KNVESYLE-- |
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| 2 |
33 |
FVCDDCSGIF C LEHRSRESHG |
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