Protein Name:
NEDD8-activating enzyme E1 catalytic subunit
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UniprotKB/SwissProt ID: Q8TBC4 (Q8TBC4)
Gene Name:
UBA3
Organism: Homo sapiens (Human)
Function: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8TBC4
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
249 |
IASMPRLPEH C IEYVRMLQWP |
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| 2 |
28 |
LAEKMAVDGG C GDTGDWEGRW |
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| 3 |
70 |
TESLQFLLDT C KVLVIGAGGL |
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