UniprotKB/SwissProt ID: Q8TAD4 (Q8TAD4)
Gene Name:
SLC30A5
Organism: Homo sapiens (Human)
Function: Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed:11904301, PubMed:15525635, PubMed:15994300, PubMed:19366695, PubMed:22529353). By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (PubMed:15525635, PubMed:15994300, PubMed:16636052, PubMed:35525268). Through the transport of zinc into secretory granules of pancreatic beta-cells, plays an important role in the storage and secretion of insulin (PubMed:11904301) Zinc ion:proton antiporter mediating influx and efflux of zinc at the plasma membrane
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus, Golgi stack membrane. Cytoplasmic vesicle, COPII-coated vesicle membrane. Cytoplasmic vesicle, secretory vesicle membrane. Golgi apparatus, trans-Golgi network membrane. Endoplasmic reticulum membrane. Cell membrane. Apical cell membrane
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