Protein Name:
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
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UniprotKB/SwissProt ID: Q8R519 (Q8R519)
Gene Name:
Acmsd
Organism: Mus musculus (Mouse)
Function: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8R519
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
221 |
VFEKFPKLKV C FAHGGGAFPF |
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| 2 |
247 |
AHGFNMRPDL C AQDNPSDPRK |
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