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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Rho guanine nucleotide exchange factor 12

UniprotKB/SwissProt ID: Q8R4H2 (Q8R4H2)

Gene Name: Arhgef12

Organism: Mus musculus (Mouse)

Function: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR037801 ARHGEF12_PH
IPR035899 DBL_dom_sf
IPR000219 DH_dom
IPR001331 GDS_CDC24_CS
IPR037884 LARG_RGS
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR041020 PH_16
IPR001849 PH_domain
IPR015212 RGS-like_dom
IPR036305 RGS_sf
IPR044926 RGS_subdomain_2