Protein Name:
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
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UniprotKB/SwissProt ID: Q8R429 (Q8R429)
Gene Name:
Atp2a1
Organism: Mus musculus (Mouse)
Function: Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum (PubMed:21697544, PubMed:22961106, PubMed:25640239, PubMed:26816378, PubMed:27923914). Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:21697544, PubMed:22961106, PubMed:25640239, PubMed:26816378)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Sarcoplasmic reticulum membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8R429
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
12 |
EAAHSKSTEE C LSYFGVSETT |
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| 2 |
344 |
RSLPSVETLG C TSVICSDKTG |
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| 3 |
349 |
VETLGCTSVI C SDKTGTLTTN |
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| 4 |
364 |
GTLTTNQMSV C KMFIIDKVDG |
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| 5 |
377 |
FIIDKVDGDV C SLNEFSITGS |
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| 6 |
417 |
YDGLVELATI C ALCNDSSLDF |
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| 7 |
420 |
LVELATICAL C NDSSLDFNET |
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| 8 |
471 |
SLSKVERANA C NSVIRQLMKK |
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| 9 |
498 |
SRDRKSMSVY C SPAKSSRAAV |
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| 10 |
525 |
KGAPEGVIDR C NYVRVGTTRV |
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| 11 |
561 |
EWGTGRDTLR C LALATRDTPP |
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| 12 |
614 |
RKEVTGSIQL C RDAGIRVIMI |
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| 13 |
636 |
GDNKGTAIAI C RRIGIFSENE |
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| 14 |
670 |
DLPLAEQREA C RRACCFARVE |
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| 15 |
674 |
AEQREACRRA C CFARVEPSHK |
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| 16 |
675 |
EQREACRRAC C FARVEPSHKS |
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