Protein Name:
Phospholipid-transporting ATPase ABCA3
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UniprotKB/SwissProt ID: Q8R420 (Q8R420)
Gene Name:
Abca3
Organism: Mus musculus (Mouse)
Function: Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant (PubMed:17142808, PubMed:17267394, PubMed:17540762, PubMed:17577581, PubMed:20190032, PubMed:28034695). Transports preferentially phosphatidylcholine containing short acyl chains (PubMed:17142808). In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endosome, multivesicular body membrane. Cytoplasmic vesicle membrane. Late endosome membrane. Lysosome membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8R420
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1594 |
LAIMVQGQFK C LGSPQHLKSK |
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