Protein Name:
Immunoglobulin superfamily member 8
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UniprotKB/SwissProt ID: Q8R366 (Q8R366)
Gene Name:
Igsf8
Organism: Mus musculus (Mouse)
Function: Member of the immunoglobulin superfamily (IgSF) that links tetraspanin-enriched microdomains to the actin cytoskeleton and plays several important roles in innate and adaptive immunity (PubMed:11673522). Acts as an inducible receptor of HSPA8 on dendritic cells to enhance the CCL21/SLC-dependent migration of activated mature dendritic cells while attenuating their antigen-specific stimulatory capacities. In complex with alpha-actinins ACTN1 and ACTN4, regulates actin dynamics in the immune synapse and subsequent T-cell activation. Inhibits the entry of several viruses such as hepatitis C Virus (HCV) or HIV-1. Mechanistically, promotes a change in CD81 organization at the plasma membrane by significantly restricting its diffusion which in turn influences CD81 interaction with Claudin-1/CLDN1, preventing CLDN1 from acting as a co-receptor required for HCV entry. Accumulates at the presynaptic terminal, the producer cell side of the virological synapse, to prevent HIV-1 Env-mediated cell-cell fusion. Highly expressed on malignant cells with antigen presentation defects, interacts with NK receptor KLRA9 to suppress NK-cell cytotoxicity (PubMed:38657602). May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain (PubMed:16203089)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8R366
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
184 |
VHEGQELALG C LAQTKTKKHT |
CCCCCCCHHH H HHHHHHHHCC |
2.71% |
24895380
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