Protein Name:
Homeodomain-only protein
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UniprotKB/SwissProt ID: Q8R1H0 (Q8R1H0)
Gene Name:
Hopx
Organism: Mus musculus (Mouse)
Function: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (PubMed:12297045, PubMed:12297046). Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8R1H0
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
34 |
VNKHPDPTTL C LIAAEAGLTE |
CCCCCCCCCC H HHHHHHHHCC |
2.13% |
21278135
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| 2 |
68 |
WRRSEGLPSE C RSVTD----- |
CCCCCCCCCC H HHHHHHHHCC |
4.63% |
21278135
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