UniprotKB/SwissProt ID: Q8R183 (Q8R183)
Gene Name:
Timd2
Organism: Mus musculus (Mouse)
Function: Cell surface glycoprotein that participates in iron homeostasis in the liver, the kidney, the retina and oligodendrocytes by acting as a receptor of H-ferritin (PubMed:16203866, PubMed:33065090). Mechanistically, mediates iron-containing ferritin uptake via an endocytic pathway, trafficking to endosomes and subsequently to lysosomes (PubMed:16043519, PubMed:21886823). Plays also an important role in the regulation of Th2 immunity (PubMed:16043519). Receptor for SEMA4A involved in the regulation of T-cell function, enhancing T-cell activation (PubMed:12374982)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane
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