Protein Name:
Valacyclovir hydrolase
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UniprotKB/SwissProt ID: Q8R164 (Q8R164)
Gene Name:
Bphl
Organism: Mus musculus (Mouse)
Function: Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8R164
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
206 |
LYGYDYLAKT C EDWVDGISQF |
CCCCCCCHHH H HHHHHHHHHH |
4.38% |
21278135
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| 2 |
234 |
ICRHLLPLVQ C PTLIVHGEKD |
CCCCCCCHHH H HHHHHHHHHH |
1.85% |
21278135
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