Protein Name:
IQ motif and SEC7 domain-containing protein 1
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UniprotKB/SwissProt ID: Q8R0S2 (Q8R0S2)
Gene Name:
Iqsec1
Organism: Mus musculus (Mouse)
Function: Guanine nucleotide exchange factor for ARF1 and ARF6. Guanine nucleotide exchange factor activity is enhanced by lipid binding. Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (By similarity). Involved in neuronal development (PubMed:31607425). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Postsynaptic density. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8R0S2
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
904 |
ESGNGTLSRA C LDDSYASGEG |
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