UniprotKB/SwissProt ID: Q8R0N9 (Q8R0N9)
Gene Name:
Zdhhc1
Organism: Mus musculus (Mouse)
Function: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as NCDN and NLRP3 (PubMed:23687301, PubMed:39173637). Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation (PubMed:23687301). Acts as an activator of the NLRP3 inflammasome by mediating palmitoylation of 'Cys-130' and 'Cys-958' of NLRP3, thereby promoting NLRP3 phosphorylation and activation by NEK7 (PubMed:39173637) Also has a palmitoyltransferase activity-independent function in DNA virus-triggered and CGAS-mediated innate immune response (PubMed:25299331). Functions as an activator of STING1 by promoting its cGAMP-induced oligomerization and the recruitment of downstream signaling components (PubMed:25299331)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endosome membrane. Endoplasmic reticulum membrane. Golgi apparatus
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