Protein Name:
Oxaloacetate tautomerase FAHD1, mitochondrial
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UniprotKB/SwissProt ID: Q8R0F8 (Q8R0F8)
Gene Name:
Fahd1
Organism: Mus musculus (Mouse)
Function: Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate (By similarity). It is thereby required to maximize aerobic respiration efficiency by preventing succinate dehydrogenase inhibition (By similarity). Also acts as a weak oxaloacetate decarboxylase (ODx), catalyzing the decarboxylation of oxaloacetate (OAA) to pyruvate and CO(2), and as such is likely a regulatory enzyme in the TCA cycle (Probable) (PubMed:25575590, PubMed:32068790). Also displays acylpyruvase activity, being able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro (PubMed:32068790)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion. Cytoplasm, cytosol
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Graphical Visualization of S-nitrosylation Sites:
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| InterPro ID |
Domain Name |
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IPR011234
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Fumarylacetoacetase-like_C |
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IPR036663
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Fumarylacetoacetase_C_sf |
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The S-nitrosylation sites of Q8R0F8
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
126 |
WTLAKSFTSS C PVSAFVPKEK |
CCCCCCCCCC C CCHHHHHCCC |
49.57% |
21278135
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| 2 |
62 |
EGSPVLMPAY C RNLHHEVELG |
CCCCCCCCCC C CCHHHHHCCC |
8.39% |
21278135
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