Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
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UniprotKB/SwissProt ID: Q8R050 (Q8R050)
Gene Name:
Gspt1
Organism: Mus musculus (Mouse)
Function: GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA. GSPT1/ERF3A mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site. GTP hydrolysis by GSPT1/ERF3A induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8R050
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
518 |
EEEILPGFIL C DLNNLCHSGR |
CCCCCCCCCC C CCCCCCCCCC |
4.84% |
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| 2 |
590 |
RPRFVKQDQV C IARLRTAGTI |
CCCCCCCCCC C CCCCCCCCCC |
1.35% |
20925432
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| 3 |
601 |
IARLRTAGTI C LETFKDFPQM |
CCCCCCCCCC C CCCCCCCCCC |
2.56% |
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