Protein Name:
NAD(P)H-hydrate epimerase
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UniprotKB/SwissProt ID: Q8NCW5 (Q8NCW5)
Gene Name:
NAXE
Organism: Homo sapiens (Human)
Function: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) (PubMed:27616477). This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity). Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (PubMed:23719382)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion. Secreted
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8NCW5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
158 |
KPLFTALVTQ C QKMDIPFLGE |
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| 2 |
283 |
LNLPPYPDTE C VYRLQ----- |
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