Protein Name:
E3 ubiquitin-protein ligase RNF169
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UniprotKB/SwissProt ID: Q8NCN4 (Q8NCN4)
Gene Name:
RNF169
Organism: Homo sapiens (Human)
Function: Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Chromosome. Nucleus, nucleoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8NCN4
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
132 |
GQADSEVLGE C ARRSQPERCR |
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| 2 |
529 |
KSSTEIPLET C CSSELKGGGS |
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| 3 |
530 |
SSTEIPLETC C SSELKGGGSG |
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