Protein Name:
Outer mitochondrial transmembrane helix translocase
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UniprotKB/SwissProt ID: Q8NBU5 (Q8NBU5)
Gene Name:
ATAD1
Organism: Homo sapiens (Human)
Function: Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (PubMed:24843043). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (By similarity). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion outer membrane. Peroxisome membrane. Postsynaptic cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8NBU5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
137 |
KGVLLYGPPG C GKTLIAKATA |
CCCHHHCCCC C CHHHHHHHHH |
6.61% |
21278135
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| 2 |
310 |
KEMCRDAALL C VREYVNSTSE |
CCCHHHCCCC C CHHHHHHHHH |
2.56% |
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| 3 |
359 |
AAFQNVLTHV C LD-------- |
CCCHHHCCCC C CHHHHHHHHH |
2.48% |
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