Protein Name:
ADP-ribosylation factor GTPase-activating protein 1
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UniprotKB/SwissProt ID: Q8N6T3 (Q8N6T3)
Gene Name:
ARFGAP1
Organism: Homo sapiens (Human)
Function: GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Golgi apparatus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8N6T3
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
351 |
RKSPSSDSWT C ADTSTERRSS |
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| 2 |
96 |
FLESQEDYDP C WSLQEKYNSR |
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