Protein Name:
eEF1A lysine and N-terminal methyltransferase
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UniprotKB/SwissProt ID: Q8N6R0 (Q8N6R0)
Gene Name:
METTL13
Organism: Homo sapiens (Human)
Function: Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore involved in the regulation of mRNA translation (PubMed:30143613, PubMed:30612740). Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N-terminal residue 'Gly-2' (PubMed:30143613). Via its N-terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55' (PubMed:30143613, PubMed:30612740). Has no activity towards core histones H2A, H2B, H3 and H4 (PubMed:30612740)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Mitochondrion
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8N6R0
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
256 |
VQERQQYAWL C SQLRRKARLG |
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| 2 |
273 |
ARLGSVSLDL C DGDTGEPRYT |
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| 3 |
587 |
DSKDPTLGMS C PPPAFVEQSF |
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| 4 |
652 |
IEGEVNEILF C QLHPEQKLAT |
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