Protein Name:
Deubiquitinase OTUD6B
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UniprotKB/SwissProt ID: Q8N6M0 (Q8N6M0)
Gene Name:
OTUD6B
Organism: Homo sapiens (Human)
Function: Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1 (PubMed:21267069, PubMed:27864334). May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation (PubMed:27864334). May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation (PubMed:27864334). May also play a role in proteasome assembly and function (PubMed:28343629) Stimulates protein synthesis. Influences the expression of CCND1/cyclin D1 by promoting its translation and regulates MYC/c-Myc protein stability
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8N6M0
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
158 |
EIKQIPSDGH C MYKAIEDQLK |
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| 2 |
172 |
AIEDQLKEKD C ALTVVALRSQ |
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| 3 |
216 |
MYTPEEFQKY C EDIVNTAAWG |
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| 4 |
292 |
TRLVNIVTEN C S--------- |
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