Protein Name:
Germinal center-associated signaling and motility protein
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UniprotKB/SwissProt ID: Q8N6F7 (Q8N6F7)
Gene Name:
GCSAM
Organism: Homo sapiens (Human)
Function: Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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| InterPro ID |
Domain Name |
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IPR031364
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GC_assoc_lym |
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