Protein Name:
Leucine-zipper-like transcriptional regulator 1
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UniprotKB/SwissProt ID: Q8N653 (Q8N653)
Gene Name:
LZTR1
Organism: Homo sapiens (Human)
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) (PubMed:30442762, PubMed:30442766, PubMed:30481304). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes (PubMed:30442762, PubMed:30442766, PubMed:30481304)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endomembrane system. Recycling endosome. Golgi apparatus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8N653
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
342 |
VGGAEVPERA C ASEEVPTLTY |
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