Protein Name:
CDGSH iron-sulfur domain-containing protein 2
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UniprotKB/SwissProt ID: Q8N5K1 (Q8N5K1)
Gene Name:
CISD2
Organism: Homo sapiens (Human)
Function: Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Mitochondrion outer membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8N5K1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
110 |
RCWRSKTFPA C DGSHNKHNEL |
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| 2 |
92 |
VVNEINIEDL C LTKAAYCRCW |
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