Protein Name:
Vacuolar protein sorting-associated protein 8 homolog
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UniprotKB/SwissProt ID: Q8N3P4 (Q8N3P4)
Gene Name:
VPS8
Organism: Homo sapiens (Human)
Function: Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes (PubMed:25266290)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Early endosome
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Graphical Visualization of S-nitrosylation Sites:
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