UniprotKB/SwissProt ID: Q8N3F8 (Q8N3F8)
Gene Name:
MICALL1
Organism: Homo sapiens (Human)
Function: Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Recycling endosome membrane. Late endosome membrane. Cell projection, cilium membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
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