Protein Name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
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UniprotKB/SwissProt ID: Q8N3E9 (Q8N3E9)
Gene Name:
PLCD3
Organism: Homo sapiens (Human)
Function: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610). Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane. Cytoplasm. Cleavage furrow
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8N3E9
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
699 |
RIEIHGVPAD C ARQETDYVLN |
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