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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Rho guanine nucleotide exchange factor 28

UniprotKB/SwissProt ID: Q8N1W1 (Q8N1W1)

Gene Name: ARHGEF28

Organism: Homo sapiens (Human)

Function: Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cell membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR037819 ARHGEF28_PH
IPR046349 C1-like_sf
IPR035899 DBL_dom_sf
IPR000219 DH_dom
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR041020 PH_16
IPR001849 PH_domain
IPR051632 Rho_GEF

The S-nitrosylation sites of Q8N1W1

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 407 TATTSPESRG C TLWPQSSKHT