UniprotKB/SwissProt ID: Q8MMZ7 (Q8MMZ7)
Gene Name:
PKG
Organism: Toxoplasma gondii
Function: Serine/threonine protein kinase which acts as a downstream effector of the second messenger cGMP (PubMed:11897122, PubMed:12455981). Plays an essential role in tachyzoite invasion of and egress from host cells (PubMed:28465425, PubMed:30753127, PubMed:31235476). During invasion of host cells, regulates the apico-basal flux of F-actin probably via Ca(2+)-mediated activation of CDPK1 (PubMed:30753127). In tachyzoites, required for microneme secretion (PubMed:26933037, PubMed:28465425). Required for tachyzoite gliding motility (PubMed:31235476) Plays an essential role in parasite invasion of and egress from host cells, and microneme secretion Dispensable for parasite invasion of and egress from host cells, and microneme secretion
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Membrane. Cell membrane. Cytoplasm
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