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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Cullin-associated NEDD8-dissociated protein 1

UniprotKB/SwissProt ID: Q8L5Y6 (Q8L5Y6)

Gene Name: CAND1

Organism: Arabidopsis thaliana (Mouse-ear cress)

Function: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (By similarity). Required for SCF(TIR1) function. Modulates SCF(TIR1) function through its interactions with the CUL1 subunit. Represses photomorphogenesis by promoting HY5 degradation in darkness

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039852 CAND1/CAND2
IPR013932 TATA-bd_TIP120

The S-nitrosylation sites of Q8L5Y6

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 604 GDQLRAELPS C LPVLVDRMGN