Protein Name:
Presequence protease, mitochondrial
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UniprotKB/SwissProt ID: Q8K411 (Q8K411)
Gene Name:
Pitrm1
Organism: Mus musculus (Mouse)
Function: Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides. It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion. It is a highly efficient protease, at least toward amyloid-beta protein 40. Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently. It is also able to degrade amyloid-beta protein 42
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion matrix
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8K411
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
556 |
TQQSKHQDAS C LPALKVSDIE |
CCCCCCCCCC C HHHHHCCCCC |
5.9% |
21278135
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| 2 |
627 |
LFCSVLTKLG C GILNYREQAQ |
CCCCCCCCCC C HHHHHCCCCC |
4.43% |
21278135
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| 3 |
780 |
KYLLNCDNMR C SVNATPQQMP |
CCCCCCCCCC C HHHHHCCCCC |
3.56% |
21278135
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