Protein Name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
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UniprotKB/SwissProt ID: Q8K2B3 (Q8K2B3)
Gene Name:
Sdha
Organism: Mus musculus (Mouse)
Function: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity). Can act as a tumor suppressor (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion inner membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8K2B3
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
189 |
KFGKGGQAHR C CCVADRTGHS |
CCCHHHHHHH H HCCCHHEECC |
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| 2 |
190 |
FGKGGQAHRC C CVADRTGHSL |
CCCHHHHHHH H HCCCHHEECC |
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| 3 |
191 |
GKGGQAHRCC C VADRTGHSLL |
CCCHHHHHHH H HCCCHHEECC |
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| 4 |
238 |
NGECRGVIAL C IEDGSIHRIR |
CCCHHHHHHH H HCCCHHEECC |
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22178444
21278135
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| 5 |
266 |
TGGYGRTYFS C TSAHTSTGDG |
CCCHHHHHHH H HCCCHHEECC |
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22178444
21278135
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| 6 |
357 |
MTLEIREGRG C GPEKDHVYLQ |
CCCHHHHHHH H HCCCHHEECC |
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21278135
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| 7 |
467 |
LLDLVVFGRA C ALSIAESCRP |
CCCHHHHHHH H HCCCHHEECC |
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| 8 |
475 |
RACALSIAES C RPGDKVPSIK |
CCCHHHHHHH H HCCCHHEECC |
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| 9 |
536 |
FRVGSVLQEG C EKISQLYGDL |
CCCHHHHHHH H HCCCHHEECC |
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21278135
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| 10 |
574 |
ETLELQNLML C ALQTIYGAEA |
CCCHHHHHHH H HCCCHHEECC |
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| 11 |
654 |
VIDKTLNEAD C ATVPPAIRSY |
CCCHHHHHHH H HCCCHHEECC |
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21278135
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| 12 |
89 |
GLSEAGFNTA C LTKLFPTRSH |
CCCHHHHHHH H HCCCHHEECC |
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22588120
21278135
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