UniprotKB/SwissProt ID: Q8K211 (Q8K211)
Gene Name:
Slc31a1
Organism: Mus musculus (Mouse)
Function: Uniporter that mediates the transport of copper(1+) from the extracellular space to the cytoplasm, across the plasma membrane (PubMed:11391005, PubMed:12177073, PubMed:16847145, PubMed:24167251). Then, delivers directly copper(1+) to specific chaperone such as ATOX1, via a copper(1+)- mediated transient interaction between the C-terminal domain and a copper(1+) chaperone, thus controlling intracellular copper(1+) levels (By similarity). May function in copper(1+) import from the apical membrane thus may drive intestinal copper absorption (PubMed:16950140). The copper(1+) transport mechanism is sodium-independent, saturable and of high-affinity (By similarity). Also mediates the uptake of silver(1+) (PubMed:20569931). May function in the influx of the platinum-containing chemotherapeutic agents (PubMed:12370430, PubMed:16847145, PubMed:19144690). The platinum-containing chemotherapeutic agents uptake is saturable (By similarity). Also participates in the first step of copper(2+) acquisition by cells through a direct transfer of copper(2+) from copper(2+) carriers in blood, such as ALB to the N-terminal domain of SLC31A1, leading to copper(2+) reduction and probably followed by copper(1+) stabilization (By similarity). In addition, functions as a redox sensor to promote angiogenesis in endothelial cells, in a copper(1+) transport independent manner, by transmitting the VEGF-induced ROS signal through a sulfenylation at Cys-195 leading to a subsequent disulfide bond formation between SLC31A1 and KDR (PubMed:35027734). The SLC31A1-KDR complex is then co-internalized to early endosomes, driving a sustained VEGFR2 signaling (By similarity) Mobilizes copper(1+) out of the endosomal compartment, making copper(1+) available for export out of the cells
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Early endosome membrane. Recycling endosome membrane. Apical cell membrane. Late endosome membrane. Basolateral cell membrane
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