UniprotKB/SwissProt ID: Q8K1Q3 (Q8K1Q3)
Gene Name:
Gpr3
Organism: Rattus norvegicus (Rat)
Function: Constitutively active G-protein coupled receptor that maintains high 3'-5'-cyclic adenosine monophosphate (cAMP) levels that a plays a role in serveral processes including meiotic arrest in oocytes or neuronal development via activation of numerous intracellular signaling pathways (PubMed:17284443). Acts as an essential activator of thermogenic adipocytes and drives thermogenesis via its intrinsic G(s)-coupling activity without the requirement of a ligand (By similarity). Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons (By similarity). Stimulates neurite outgrowth in cerebellar granular neurons modulated via PKA, ERK, and most strongly PI3K-mediated signaling pathways (PubMed:34871769)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane
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