Protein Name:
E3 ubiquitin-protein ligase PPP1R11
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UniprotKB/SwissProt ID: Q8K1L5 (Q8K1L5)
Gene Name:
Ppp1r11
Organism: Mus musculus (Mouse)
Function: Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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