Protein Name:
Transmembrane protein 41B
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UniprotKB/SwissProt ID: Q8K1A5 (Q8K1A5)
Gene Name:
Tmem41b
Organism: Mus musculus (Mouse)
Function: Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes. Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine. Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly. In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (By similarity). Required for normal motor neuron development (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Endomembrane system
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8K1A5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
44 |
GSKDHLNEKP C AEAGSARTSL |
CCCCCCCCCC C CHHHHCCCCC |
8.72% |
21278135
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