UniprotKB/SwissProt ID: Q8JZZ7 (Q8JZZ7)
Gene Name:
Adgrl2
Organism: Mus musculus (Mouse)
Function: Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (PubMed:28972101, PubMed:30792275). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity (PubMed:24273166, PubMed:30792275). Specifically mediates the establishment of perforant-path synapses on CA1-region pyramidal neurons in the hippocampus (PubMed:28972101, PubMed:30792275). Localizes to postsynaptic spines in excitatory synapses in the S.lacunosum-moleculare and interacts with presynaptic cell adhesion molecules, such as teneurins, promoting synapse formation (PubMed:30792275)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Postsynaptic cell membrane
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