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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Complex I assembly factor ACAD9, mitochondrial

UniprotKB/SwissProt ID: Q8JZN5 (Q8JZN5)

Gene Name: Acad9

Organism: Mus musculus (Mouse)

Function: As part of the MCIA complex, primarily participates in the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphorylation. This moonlighting protein also has a dehydrogenase activity toward a broad range of substrates with greater specificity for long-chain unsaturated acyl-CoAs. However, in vivo, it does not seem to play a primary role in fatty acid oxidation. In addition, the function in complex I assembly is independent of the dehydrogenase activity of the protein

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion inner membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR049448 ACAD9/ACADV-like_C
IPR006089 Acyl-CoA_DH_CS
IPR006091 Acyl-CoA_Oxase/DH_mid-dom
IPR046373 Acyl-CoA_Oxase/DH_mid-dom_sf
IPR036250 AcylCo_DH-like_C
IPR009075 AcylCo_DH/oxidase_C
IPR013786 AcylCoA_DH/ox_N
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom_sf

The S-nitrosylation sites of Q8JZN5

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 183 LSSGEHIAAF C LTEPASGSDA  CCCEEEECHH H HHHHHHHHHH  3.84% 21278135
2 275 DKLGIRGSNT C EVHFENTRVP  CCCEEEECHH H HHHHHHHHHH  6.34% 21278135
3 331 KLIELTAEYA C TRKQFNRNLS  CCCEEEECHH H HHHHHHHHHH  3.56% 22178444
4 617 RQILEKRAYI C AHPLDRAS--  CCCEEEECHH H HHHHHHHHHH  1.53% 22178444
21278135