Protein Name:
Dimethyladenosine transferase 1, mitochondrial
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UniprotKB/SwissProt ID: Q8JZM0 (Q8JZM0)
Gene Name:
Tfb1m
Organism: Mus musculus (Mouse)
Function: Mitochondrial methyltransferase which uses S-adenosyl methionine to dimethylate two highly conserved adjacent adenosine residues (A1006 and A1007) within the loop of helix 45 at the 3-prime end of 12S rRNA, thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome (PubMed:19356719). Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion
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Graphical Visualization of S-nitrosylation Sites:
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