Protein Name:
5'-3' exoribonuclease 1
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UniprotKB/SwissProt ID: Q8IZH2 (Q8IZH2)
Gene Name:
XRN1
Organism: Homo sapiens (Human)
Function: Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8IZH2
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1104 |
GVIPDRDAEF C LFDRVVNVRE |
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| 2 |
132 |
LPTEARFDSN C ITPGTEFMAR |
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| 3 |
16 |
FYRWISERYP C LSEVVKEHQI |
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| 4 |
398 |
KKLKGQENSL C WTALDKNEGE |
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| 5 |
869 |
VFMLGTPYYG C TGEVQDSGDV |
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