Protein Name:
tRNA (uracil-5-)-methyltransferase homolog A
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UniprotKB/SwissProt ID: Q8IZ69 (Q8IZ69)
Gene Name:
TRMT2A
Organism: Homo sapiens (Human)
Function: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and some mRNAs (PubMed:31361898, PubMed:33799331, PubMed:34556860). Mainly catalyzes the methylation of uridine at position 54 (m5U54) in cytosolic tRNAs (PubMed:31361898, PubMed:33799331). Also able to mediate the formation of 5-methyl-uridine in some mRNAs (PubMed:34123281)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8IZ69
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
225 |
EQRHKHNKAC C PLEGVRPSPQ |
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| 2 |
260 |
GVDGEDNTVG C RLGKYKGGTC |
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| 3 |
365 |
AGPGRASGVT C LYFVEEGQRK |
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| 4 |
392 |
LPLEHVAGDR C IHEDLLGLTF |
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| 5 |
463 |
KVKRVIGVEL C PEAVEDARVN |
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