UniprotKB/SwissProt ID: Q8IYC8 (Q8IYC8)
Gene Name:
BACE1
Organism: Homo sapiens (Human)
Function: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. Cleaves CHL1
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cell projection, axon. Cell projection, dendrite. Cell surface. Cytoplasmic vesicle membrane. Early endosome. Endoplasmic reticulum. Golgi apparatus, trans-Golgi network. Late endosome. Lysosome. Membrane raft. Recycling endosome
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