Protein Name:
ATP-dependent RNA helicase SUPV3L1, mitochondrial
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UniprotKB/SwissProt ID: Q8IYB8 (Q8IYB8)
Gene Name:
SUPV3L1
Organism: Homo sapiens (Human)
Function: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8IYB8
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
175 |
HAKQIFPVLD C KDDLRKISDL |
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| 2 |
230 |
KYFSAKSGVY C GPLKLLAHEI |
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| 3 |
251 |
FEKSNAAGVP C DLVTGEERVT |
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| 4 |
418 |
AKKFNDPNDP C KILVATDAIG |
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