Protein Name:
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2
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UniprotKB/SwissProt ID: Q8IXW5 (Q8IXW5)
Gene Name:
RPAP2
Organism: Homo sapiens (Human)
Function: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (PubMed:17643375, PubMed:22137580, PubMed:24997600). Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (PubMed:30118681)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8IXW5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
185 |
SGHSGEEVQL C SKAIKTSDID |
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| 2 |
288 |
KLDSQEKDAT C ELPLQKVNTQ |
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| 3 |
358 |
SRSVSSSVQV C PEVGKRNLLK |
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