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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Ankyrin repeat and KH domain-containing protein 1

UniprotKB/SwissProt ID: Q8IWZ3 (Q8IWZ3)

Gene Name: ANKHD1

Organism: Homo sapiens (Human)

Function: May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR051631 Ankyrin-KH/SAM_domain
IPR002110 Ankyrin_rpt
IPR036770 Ankyrin_rpt-contain_sf
IPR047374 KH-I_ANKHD1
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf

The S-nitrosylation sites of Q8IWZ3

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1130 RTKDTPLSLA C SGGRQEVVDL  CCCCCCCCCC C HHHHHHHCCC  4.75%
2 1601 SDSDNLDSTD C NSESSSGGKS  CCCCCCCCCC C HHHHHHHCCC  6.47%
3 181 VLRRLTSSVS C ALDEAAAALT  CCCCCCCCCC C HHHHHHHCCC  4.01% 24105792
4 213 QVDTRSLAEA C SDGDVNAVRK  CCCCCCCCCC C HHHHHHHCCC  2.61% 24105792
5 2518 MIKVIQNSTE C TDAQQIWPGT  CCCCCCCCCC C HHHHHHHCCC  4.17%
6 380 EFKESALTLA C YKGHLDMVRF  CCCCCCCCCC C HHHHHHHCCC  3.97% 24105792
7 447 SFESPLTLAA C GGHVELAALL  CCCCCCCCCC C HHHHHHHCCC  5.81%
8 535 IKAGADIELG C STPLMEASQE  CCCCCCCCCC C HHHHHHHCCC  6.82% 24105792
9 576 ATGDTALTYA C ENGHTDVADV  CCCCCCCCCC C HHHHHHHCCC  2.69%