Protein Name:
Pleckstrin homology domain-containing family M member 2
|
UniprotKB/SwissProt ID: Q8IWE5 (Q8IWE5)
Gene Name:
PLEKHM2
Organism: Homo sapiens (Human)
Function: Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:22172677, PubMed:24088571, PubMed:25898167, PubMed:28325809). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Lysosome membrane
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q8IWE5
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
307 |
EAQALDPPDA C TELEVIRVTK |
|
|
|
| 2 |
551 |
EPEPGTQEVL C QLKRDQPSPC |
|
|
|
|
