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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: D-2-hydroxyglutarate dehydrogenase, mitochondrial

UniprotKB/SwissProt ID: Q8CIM3 (Q8CIM3)

Gene Name: D2hgdh

Organism: Mus musculus (Mouse)

Function: Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate (By similarity). Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC) (By similarity). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR004113 FAD-bd_oxidored_4_C
IPR016166 FAD-bd_PCMH
IPR036318 FAD-bd_PCMH-like_sf
IPR016167 FAD-bd_PCMH_sub1
IPR016169 FAD-bd_PCMH_sub2
IPR016164 FAD-linked_Oxase-like_C
IPR051264 FAD-oxidored/transferase_4
IPR006094 Oxid_FAD_bind_N
IPR016171 Vanillyl_alc_oxidase_C-sub2

The S-nitrosylation sites of Q8CIM3

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 212 MPLDLGAKGS C HIGGNVATNA  CCCCCCCHHH E EEEECCCCHH  3.55%
2 37 RACVGLKRLG C PRGVYSPLAH  CCCCCCCHHH E EEEECCCCHH  2.16% 21278135