UniprotKB/SwissProt ID: Q8CI59 (Q8CI59)
Gene Name:
Steap3
Organism: Mus musculus (Mouse)
Function: Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (PubMed:16227996, PubMed:16609065, PubMed:18955558). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (PubMed:16609065). Mediates efficient transferrin-dependent iron uptake in erythroid cells (PubMed:16227996). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression (By similarity). Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endosome membrane
|
|
|
