UniprotKB/SwissProt ID: Q8CGB6 (Q8CGB6)
Gene Name:
Tns2
Organism: Mus musculus (Mouse)
Function: Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (By similarity). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (By similarity). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy. Negatively regulates PI3K-AKT pathway activation (By similarity). Dephosphorylates nephrin NPHS1 in podocytes which affects mTORC1 complex activity (By similarity). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (By similarity). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (PubMed:27246398, PubMed:31723089, PubMed:32390516). Enhances RHOA activation in the presence of DLC1 (By similarity). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell junction, focal adhesion. Cell membrane. Cytoplasm
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