UniprotKB/SwissProt ID: Q8CG14 (Q8CG14)
Gene Name:
C1s1
Organism: Mus musculus (Mouse)
Function: Component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C1S is activated following association of the C1 complex with immunoglobulins (IgG or IgM) complexed with antigens to form antigen-antibody complexes on the surface of pathogens. C1S is cleaved and activated by C1R to generate C1s subcomponent heavy and light chains. C1s subcomponent light chain then cleaves and activates C2 and C4, the next components of the classical complement pathway Serine protease component of the complement C1 complex, which catalyzes cleavage and activation of C2 and C4, the next components of the classical complement pathway. Also cleaves IGFBP5 and thereby inhibits the trophic effects of IGF1
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted. Cell surface
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